abstract：:The medical response to radiation--whether the result of radiological warfare, terrorist deployment of improvised radiation dispersal weapons, political assassination, occupational or industrial accidents or the medically radiated patient remains one of the least taught among all disciplines within medical education. ...

journal_title：Seminars in diagnostic pathology

authors： McFee RB,Leikin JB

更新日期：2009-02-01 00:00:00

abstract：:Most conventional anticancer drugs act by preventing cells from dividing or have toxic effects on dividing cells, but the toxic effects on the normal cells in the body limit the dosage to a level below that which is effective for complete response. There has been a search for more specific agents that have a much grea...

journal_title：Seminars in diagnostic pathology

authors： Lopez-Beltran A,Kirkali Z,Cheng L,Egevad L,Regueiro JC,Blanca A,Montironi R

更新日期：2008-11-01 00:00:00

abstract：:Lipomatous lesions of the heart and cystic tumor of the atrioventricular node are not common. A pathologist will only rarely encounter these entities, and in the case of the atrioventricular node tumor, only if they examine the conduction system. Most fatty lesions are not clinically significant; however, arrhythmias,...

journal_title：Seminars in diagnostic pathology

authors： Veinot JP

更新日期：2008-02-01 00:00:00

abstract：:Pulmonary lesions encountered by the pathologist in which histiocytes are the dominant finding histologically are reviewed. Lesions discussed include neoplasms of histiocytes and nonneoplastic processes. The nonneoplastic processes are divided into those that present as nodular histiocytic proliferations in the lung, ...

journal_title：Seminars in diagnostic pathology

authors： Wang CW,Colby TV

更新日期：2007-08-01 00:00:00

abstract：:Malpractice actions against surgical pathologists are still relatively uncommon, but they have increased in frequency over time and are associated with sizable indemnity figures. This discussion categorizes areas of liability in surgical pathology into three groups: those that represent health system flaws (problems w...

journal_title：Seminars in diagnostic pathology

authors： Wick MR

更新日期：2007-05-01 00:00:00

abstract：:Any discussion of multiple pregnancy figures prominently in the consideration of the medicolegal aspects of placental pathology. Multiple gestations are common and becoming more so with assisted reproductive techniques, and multiples are associated with a disproportionate share of complications that may result in disp...

journal_title：Seminars in diagnostic pathology

authors： Gersell DJ

更新日期：2007-02-01 00:00:00

abstract：:Histological assessments continue to have an important role in the diagnosis and management of graft complications following liver transplantation. For some conditions, such as liver allograft rejection, histology is regarded as the "gold standard" for diagnosis. In other cases, where a likely cause of graft dysfuncti...

journal_title：Seminars in diagnostic pathology

authors： Hübscher SG

更新日期：2006-08-01 00:00:00

abstract：:Gastrointestinal (GI) stromal tumors (GISTs) are the most common mesenchymal tumors specific to the GI tract, generally defined as KIT (CD117)-positive tumors with a characteristic set of histologic features. These tumors, derived from Cajal cells or their precursors, most commonly occur at the age >50 years in the st...

journal_title：Seminars in diagnostic pathology

authors： Miettinen M,Lasota J

更新日期：2006-05-01 00:00:00

abstract：:This paper examines the spectrum of challenges that confront the diagnostic surgical pathologist in distinguishing benign mesothelial hyperplasia from malignant mesothelioma. The current state of the art with respect to the morphological, immunohistological, and molecular features that can assist in the evaluation of ...

journal_title：Seminars in diagnostic pathology

authors： Kradin RL,Mark EJ

更新日期：2006-02-01 00:00:00

abstract：:Perhaps due to the increasing use of sensitive cross-sectional imaging of the abdomen, cystic lesions of the pancreas are being increasingly recognized. In many such cases, biopsy or resection reveals a multilocular cyst lined by columnar mucinous epithelium. Over the past two to three decades, there have been many ad...

journal_title：Seminars in diagnostic pathology

authors： Klimstra DS

更新日期：2005-11-01 00:00:00

abstract：:The morphologic classification of thymoma has undergone numerous revisions in recent years and has been under continuous debate for the past several decades. With the introduction of the World Health Organization (WHO) schema for the classification of thymic epithelial neoplasms in 1999, a major step was taken toward ...

journal_title：Seminars in diagnostic pathology

authors： Suster S,Moran CA

更新日期：2005-08-01 00:00:00

abstract：:Contrary to the intuitive impression of most pathologists, there are still many areas in laboratory medicine where evidence-based medicine (EBM) principles are not applied. These include aspects of both anatomic and clinical pathology. Some non-EBM practices are perpetuated by clinical "consumers" of laboratory servic...

journal_title：Seminars in diagnostic pathology

authors： Wick MR,Bourne TD,Patterson JW,Mills SE

更新日期：2005-05-01 00:00:00

abstract：:The spectrum of neoplasms involving the urinary bladder is diverse, and, at times, different entities with distinct prognostic and managerial implications may have significant morphologic overlap. The presence of a neoplasm with an unusual morphologic appearance, such as an undifferentiated spindled, or plasmacytoid p...

journal_title：Seminars in diagnostic pathology

authors： McKenney JK,Amin MB

更新日期：2005-02-01 00:00:00

abstract：:Acute pancreatitis is characterized by the occurrence of necroinflammatory changes in the pancreas. Three types of necrosis may be distinguished: (1) interstitial tissue necrosis, which subsequently may also involve acinar and ductal cells, (2) ductal necrosis, and (3) acinar necrosis. The first type of necrosis is au...

journal_title：Seminars in diagnostic pathology

authors： Klöppel G

更新日期：2004-11-01 00:00:00

abstract：:Granulomatous appendicitis is a rare condition, accounting for less than 2% of all cases of appendicitis. The initial belief that it represented a manifestation of Crohn's disease is incorrect in the great majority of cases, as only 5-10% of patients with granulomatous appendicitis develop Crohn's disease elsewhere in...

journal_title：Seminars in diagnostic pathology

authors： Bronner MP

更新日期：2004-05-01 00:00:00

abstract：:Spindle cell lesions of the breast constitute a wide spectrum of benign and malignant proliferations. Myofibroblasts, normal cellular constituents of the mammary intra- and interlobular stroma, compose many of these lesions, which include reactive proliferations and benign or locally aggressive neoplasms. Because of i...

journal_title：Seminars in diagnostic pathology

authors： Brogi E

更新日期：2004-02-01 00:00:00

abstract：:Varied mesothelial proliferations are found around the testes. Benign reactive mesothelial proliferations in hydrocoeles may be very florid and histologically worrisome, but these can usually be separated from malignant mesotheliomas of the tunica vaginalis because they are confined to a sharply demarcated zone near t...

journal_title：Seminars in diagnostic pathology

authors： Churg A

更新日期：2003-11-01 00:00:00

abstract：:Modern diagnosis of mature B- and T-cell leukemias requires integration of morphologic, immunophenotypic, and molecular genetic features. This integrative approach has allowed more precise definitions of specific disease entities. This in turn provides better information for clinicians to select proper therapy and det...

journal_title：Seminars in diagnostic pathology

authors： Hsi ED,Mirza I

更新日期：2003-08-01 00:00:00

abstract：:The intraoperative and on-site cytopathology can be successfully performed with a number of smear preparations. Specimen concentration technique is the preferred method. The Romanowsky stain such as Diff Quik used in our laboratory is economical, convenient, reproducible, and quick. This can be at times combined with ...

journal_title：Seminars in diagnostic pathology

authors： Gupta PK,Baloch ZW

更新日期：2002-11-01 00:00:00

abstract：:Although many of the vasculitides within the classification of the American College of Rheumatology can have a component of granulomatous inflammation with giant cells, two (ie, giant-cell [temporal] arteritis and Takayasu arteritis) are characterized by infiltrates that are dominated by granulomatous and/or giant-cel...

journal_title：Seminars in diagnostic pathology

authors： Weidner N

更新日期：2001-02-01 00:00:00

abstract：:Neoplasms of the pancreas usually show either ductal, acinar, or endocrine differentiation. Mixed exocrine-endocrine pancreatic neoplasms, in which the endocrine component is significant and comprises one-third to one-half of the tumor tissue, are rare. Truly mixed tumors have to be distinguished from exocrine neoplas...

journal_title：Seminars in diagnostic pathology

authors： Klöppel G

更新日期：2000-05-01 00:00:00

abstract：:Odontogenic ghost cell tumor is a rare epithelial odontogenic tumor that is the neoplastic counterpart of the calcifying odontogenic cyst. There is confusion and controversy in the literature regarding the integration or segregation of these 2 lesions. It shows many histologic features with ameloblastoma but in additi...

journal_title：Seminars in diagnostic pathology

authors： Ellis GL

更新日期：1999-11-01 00:00:00

abstract：:The pathologic spectrum of breast disease in children and adolescents is broad and includes entities more commonly seen in older patients. In general, the vast majority of breast masses in young patients are benign with fibroadenomas, gynecomastia, and macromastia accounting for the majority of surgical specimens. Mal...

journal_title：Seminars in diagnostic pathology

authors： Dehner LP,Hill DA,Deschryver K

更新日期：1999-08-01 00:00:00

abstract：:A great variety of oxyphilic tumors and tumor-like lesions occur in the female and male genital tracts, particularly in the former. The ovary is the site of a wider range of oxyphilic tumors than any other organ. Not only are its most highly specialized steroid hormone-secreting tumors and tumor-like lesions often com...

journal_title：Seminars in diagnostic pathology

authors： Young RH,Scully RE

更新日期：1999-05-01 00:00:00

abstract：:Primary thymic epithelial neoplasms have been the source of much controversy over the years because of difficulties in their histopathologic classification and prognostication of clinical behavior. Despite recent advances in our understanding of the immunopathology and molecular pathology of these neoplasms, no univer...

journal_title：Seminars in diagnostic pathology

authors： Suster S,Moran CA

更新日期：1999-02-01 00:00:00

abstract：:Pediatric liver disease may require specialized evaluation with abstruse techniques. We present suggestions to permit pathologists who do not work at pediatric referral hospitals to handle liver biopsy specimens from pediatric patients so that information will not be lost. ...

journal_title：Seminars in diagnostic pathology

authors： Finn LS,Knisely AS

更新日期：1998-11-01 00:00:00

abstract：:Nevoid malignant melanoma probably represents an early form of nodular malignant melanoma in which there is little proliferation of melanocytes in the epidermis and a dermal proliferation that mimics some features of a compound or intradermal nevus, which is difficult to recognize as being due to malignant melanoma. T...

journal_title：Seminars in diagnostic pathology

authors： McNutt NS

更新日期：1998-08-01 00:00:00

abstract：:Bladder neoplasia of the transitional cell type progresses by two distinct, but occasionally interrelated, pathways characterized morphologically by a papillary or nonpapillary configuration. In this review, the authors discuss intraepithelial lesions of the urinary bladder, le, those lesions confined within the basem...

journal_title：Seminars in diagnostic pathology

authors： Amin MB,Young RH

更新日期：1997-05-01 00:00:00

abstract：:Despite extensive epidemiological evidence suggesting that Kaposi's sarcoma (KS) has an infectious origin, a specific viral association with KS had not been documented until recently, when two novel DNA fragments were identified in KS lesional tissue from a patient with the acquired immunodeficiency syndrome (AIDS). T...

journal_title：Seminars in diagnostic pathology

authors： Cesarman E,Knowles DM

更新日期：1997-02-01 00:00:00

abstract：:Most malignant epithelial tumors of the gallbladder are heterogenous and classified as adenocarcinomas. The authors report a previously unrecognized group of unusual gallbladder carcinomas including two cases of signet ring cell carcinoma in situ, three of cribriform invasive adenocarcinoma, and one of adenocarcinoma ...

journal_title：Seminars in diagnostic pathology

authors： Albores-Saavedra J,Molberg K,Henson DE

更新日期：1996-11-01 00:00:00

abstract：:Desmoplastic small round cell tumor is an undifferentiated tumor associated with serosal surfaces, especially the peritoneum. It is found predominantly in adolescents and young adults and is much more common in males than in females. The tumor has a characteristic histology, with extensive stromal tissue around island...

journal_title：Seminars in diagnostic pathology

authors： Leuschner I,Radig K,Harms D

更新日期：1996-08-01 00:00:00

abstract：:Myoepitheliomas of the salivary glands remain a controversial entity. To contribute to the knowledge of this entity, 16 myoepithelial tumors of the salivary glands were studied: 12 benign myoepitheliomas (BME) and 4 malignant myoepitheliomas (MME). The clinical and the histologic findings of each case were studied Imm...

journal_title：Seminars in diagnostic pathology

authors： Alós L,Cardesa A,Bombí JA,Mallofré C,Cuchi A,Traserra J

更新日期：1996-05-01 00:00:00

abstract：:The malignant rhabdoid tumor (MRT) has been a controversial lesion since its seminal description. There is no consensus as to whether it represents a distinctive clinicopathological entity or, alternatively, a phenotypic pattern that is potentially common to several disparate neoplasms. MRT of the kidney is a childhoo...

journal_title：Seminars in diagnostic pathology

authors： Wick MR,Ritter JH,Dehner LP

更新日期：1995-08-01 00:00:00

abstract：:Unusual lung tumors of uncertain origin have been described briefly concerning benign clear cell (sugar) tumor and, in more detail, concerning pneumocytoma (so-called sclerosing hemangioma). Melanocytic differentiation of clear cell tumor, which is peculiar to the lung, has been suggested recently. Sclerosing hemangio...

journal_title：Seminars in diagnostic pathology

authors： Shimosato Y

更新日期：1995-05-01 00:00:00

abstract：:The most important routine vehicle for communication in surgical pathology is the specimen report. Although accuracy, clarity and thoroughness are the main goals, significant variability in format and content exists. In an effort to make reports more consistent, several mechanisms are useful and amenable for use in a ...

journal_title：Seminars in diagnostic pathology

authors： Leslie KO,Rosai J

更新日期：1994-11-01 00:00:00

abstract：:The conservation treatment of ductal carcinoma in situ (DCIS) is based on the surgical excision of the tumour together with irradiation of the remaining breast. Because short-term recurrence is almost certainly caused by residual tumour, an attempt should be made to verify the adequacy of the excision by assessing the...

journal_title：Seminars in diagnostic pathology

authors： Faverly DR,Burgers L,Bult P,Holland R

更新日期：1994-08-01 00:00:00

abstract：:The histogenetic approach to the classification of embryonal tumors of the central nervous system has historically received wide acceptance as a scheme for histologic typing and nosologic definition. Medulloblastoma is a paradigm of a neuroblastic neoplasm whose origins and differentiation potential are traceable to c...

journal_title：Seminars in diagnostic pathology

authors： Katsetos CD,Burger PC

更新日期：1994-05-01 00:00:00

abstract：:The first requirement of a new prognostic indicator is that it should possess a clear biological significance. Indeed, much evidence shows that tumor growth and metastasis depend on neovascularization. Tumor angiogenesis (TA) refers to the growth of new vessels toward and within the tumor; unless tumor neovascularizat...

journal_title：Seminars in diagnostic pathology

authors： Weidner N

更新日期：1993-11-01 00:00:00

abstract：:Workshop C included cases with a differential diagnosis of Hodgkin's disease and B cell lymphoma. In general, the cases could be placed into one of the following four major categories: (1) usual Hodgkin's disease versus T cell-rich B cell lymphoma; (2) syncytial Hodgkin's disease versus B large cell lymphoma; (3) nodu...

journal_title：Seminars in diagnostic pathology

authors： Warnke RA

更新日期：1992-11-01 00:00:00

abstract：:For evaluating the therapeutic approaches in the follow-up and complications of patients treated with bone marrow transplantation (BMT), the histopathology is important on many occasions. The authors describe the different morphological changes that have an important role for treatment of these patients, classified ac...

journal_title：Seminars in diagnostic pathology

authors： Bombi JA,Palou J,Bruguera M,Feliu E,Martin-Ortega E,Rozman C,Cardesa A

更新日期：1992-08-01 00:00:00